Clinical classification systems and long-term outcome in mid- and late-stage Parkinson's disease.

ABSTRACT: Parkinson's disease shows a heterogeneous course and different clinical subtyping systems have been described. To compare the capabilities of two clinical classification systems, motor-phenotypes, and a simplified clinical motor-nonmotor subtyping system, a cohort was included at mean 7.9 ± 5.3 years of disease duration, classified using both clinical systems, and reexamined and reclassified at the end of an observation period. Time-points were retrospectively extracted for five major disease milestones: death, dementia, Hoehn and Yahr stage 5, nursing home living, and walking aid use. Eighty-nine patients were observed for 8.1 ± 2.7 years after inclusion. Dementia developed in 32.9% of the patients and 36.0-67.4% reached the other milestones. Motor-phenotypes were unable to stratify risks

SUBMITTER: Ygland Rodstrom E 

PROVIDER: S-EPMC8329298 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature