Infectious Complications Predict Premature CD8⁺ T-cell Senescence in CD40 Ligand-Deficient Patients.

ABSTRACT:

Purpose

CD40 ligand (CD40L)-deficient patients display increased susceptibilities to infections that can be mitigated with effective prophylactic strategies including immunoglobulin G (IgG) replacement and prophylactic antibiotics. CD8⁺ T-cell senescence has been described in CD40L deficiency, but it is unclear if this is an intrinsic feature of the disease or secondary to infectious exposures. To address this question, we assessed CD8⁺ T-cell senescence and its relationship to clinical histories, including prophylaxis adherence and infections, in CD40L-deficient patients.

Methods

Peripheral CD8⁺ T-cells from seven CD40L-deficient patients and healthy controls (HCs) were assessed for senescent features using T-cell receptor excision circle (T

SUBMITTER: Shin JJ 

PROVIDER: S-EPMC8329305 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature