Association between Alcohol Consumption and Serum Cortisol Levels: a Mendelian Randomization Study.

ABSTRACT:

Background

Several studies have reported conflicting results regarding the relationship between alcohol consumption and cortisol levels. However, the causality between alcohol consumption and cortisol levels has not been evaluated.

Methods

This study examined 8,922 participants from the Dong-gu Study. The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism was used as an instrumental variable for alcohol consumption. The association between the genetically predicted alcohol consumption and cortisol level was evaluated with Mendelian randomization (MR) using two-stage least squares regression.

Results

Alcohol consumption was positively associated with the serum cortisol level in both sexes in the observational analysis. In the MR analysis, the genetically predicted alc

SUBMITTER: Yang JH 

PROVIDER: S-EPMC8329388 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature