Evaluation of Microwave Ablation in 4T1 Breast Tumor by a Novel VEFGR2 Targeted Ultrasound Contrast Agents.

ABSTRACT:

Objectives

A novel ultrasound contrast agent (UCA) VEGFR2-targeting iron-doped silica (SiO₂) hollow nanoparticles (VEGFR2-PEG-HSNs-Fe NPs) was prepared and applied in microwave ablation for breast cancer to investigate its value in the evaluation of effectiveness after tumor ablation.

Methods

VEGFR2-PEG-HSNs-Fe NPs were prepared by using nano-SiO₂, which was regarded as a substrate and etched by ferrous acetate, and then modified with anti-VEGFR2 antibody. Laser confocal microscope and flow cytometry were used to observe its main physicochemical properties, and biological safety was also investigated. After the xenograft tumor was treated with microwave ablation, the extent of perfusion defect was evaluated by ultrasound by injecting VEGFR2-PEG-HSNs-Fe

SUBMITTER: Li X 

PROVIDER: S-EPMC8329532 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature