YAP1-MAML2 Fusion as a Diagnostic Biomarker for Metaplastic Thymoma.

ABSTRACT:

Background

Metaplastic thymoma is a very rare tumor with only a few case reports documented in literature. Hence, its molecular features have not been well explored.

Material and methods

Seventeen specimens of metaplastic thymoma were sequenced and retrospectively analyzed by fluorescence in situ hybridization (FISH) and immunohistochemistry in the study. In addition, seven cases of micronodular thymoma with lymphoid stroma and nine cases of type A thymoma were also investigated.

Results

Among these metaplastic thymomas, fifteen cases showed classical histological features, and two cases displayed characteristic micronodular-like growth patterns. DNA and RNA based next-generation sequencing identified and confirmed highly recurrent Yes Associated Protein 1 (

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8329546 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature