Associations of immunological features with COVID-19 severity: a systematic review and meta-analysis.

ABSTRACT:

Background

COVID-19 has spread widely worldwide, causing millions of deaths. We aim to explore the association of immunological features with COVID-19 severity.

Methods

We conducted a meta-analysis to estimate mean difference (MD) of immune cells and cytokines levels with COVID-19 severity in PubMed, Web of Science, Scopus, the Cochrane Library and the grey literature.

Results

A total of 21 studies with 2033 COVID-19 patients were included. Compared with mild cases, severe cases showed significantly lower levels of immune cells including CD3⁺ T cell (× 10⁶, MD, - 413.87; 95%CI, - 611.39 to - 216.34), CD4⁺ T cell (× 10⁶, MD, - 203.56; 95%CI, - 277.94 to - 129.18), CD8⁺ T cell (× 10⁶, MD, - 128.88; 95%CI,

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8329624 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature