The N⁶-Methyladenosine-Modified Pseudogene HSPA7 Correlates With the Tumor Microenvironment and Predicts the Response to Immune Checkpoint Therapy in Glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM), one of the most aggressive tumors of the brain, has no effective or sufficient therapies. Identifying robust biomarkers for the response to immune checkpoint blockade (ICB) therapy, a promising treatment option for GBM patients, is urgently needed.

Methods

We comprehensively evaluated lncRNA m⁶A modification patterns in m⁶A-sequencing (m⁶A-seq) data for GBM tissues and systematically investigated the immune and stromal regulators of these m⁶A-regulated lncRNAs. We used the single-sample gene-set enrichment analysis (ssGSEA) algorithm to investigate the difference in enriched tumor microenvironment (TME) infiltrating cells and the functional annotation of HSPA7 in individual GBM samples. Further, we va

SUBMITTER: Zhao R 

PROVIDER: S-EPMC8329659 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature