Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations.

ABSTRACT: Chronic and acute stress differentially affect behavior as well as the structural integrity of the hippocampus, a key brain region involved in cognition and memory. However, it remains unclear if and how the facilitatory effects of acute stress on hippocampal information coding are disrupted as the stress becomes chronic. To examine this, we compared the impact of acute and chronic stress on neural activity in the CA1 subregion of male mice subjected to a chronic immobilization stress (CIS) paradigm. We observed that following first exposure to stress (acute stress), the spatial information encoded in the hippocampus sharpened, and the neurons became increasingly tuned to the underlying theta oscillations in the local field potential (LFP). However, following repeated exposure to the same

SUBMITTER: Tomar A 

PROVIDER: S-EPMC8329706 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature