A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants.

ABSTRACT:

Background/objectives

In Samoa, where 80% of the adult population is living with obesity, understanding the determinants of adiposity and growth during infancy may inform prevention efforts. We examined the association of a missense variant, rs373863828, in the CREBRF gene with body composition in Samoan infants. Adults with one or more copies of the rs373863828 minor allele (A) have higher odds of obesity, based on body-mass index (BMI), but paradoxically decreased odds of diabetes compared to those without the allele. Our study may offer novel insight into the natural history and pathogenesis of this unexpected relationship.

Subjects/methods

In a prospective study, we measured body composition in early infancy, and at 2- and 4-months of age using anthropometry and dual-ene

SUBMITTER: Arslanian KJ 

PROVIDER: S-EPMC8329753 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature