Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway.

ABSTRACT: Diabetic nephropathy (DN) is a common complication in patients with diabetes and a leading cause of mortality. The management of DN in the clinic still remains a challenge. Therefore, the identification of novel compounds for DN treatment and their characterization in preclinical DN models are crucial. Isoeucommin A is a lignan compound isolated from Eucommia ulmoides Oliv, which has not been studied in detail. Our aim was to investigate the effect of Isoeucommin A in DN and to elucidate the molecular mechanisms though which Isoeucommin A acts in vitro and in vivo. We first isolated and purified Isoeucommin A by microporous resin column chromatography and studied the mass spectrogram, as well as the structure of Isoeucommin A, by high-resolution electrospray ionization mass spectroscopy an

SUBMITTER: Huang Q 

PROVIDER: S-EPMC8329780 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature