Interleukin 6 as a marker of severe bacterial infection in children with sickle cell disease and fever: a case-control study.

ABSTRACT:

Background

Etiological diagnosis of fever in children with sickle cell disease (SCD) is often challenging. The aim of this study was to analyze the pattern of inflammatory biomarkers in SCD febrile children and controls, in order to determine predictors of severe bacterial infection (SBI).

Methods

A prospective, case-control study was carried out during 3 years, including patients younger than 18 years with SCD and fever (cases) and asymptomatic steady-state SCD children (controls). Clinical characteristics and laboratory parameters, including 10 serum proinflammatory cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17a, IFN-γ and TNF-α) and comparisons among study subgroups were analyzed.

Results

A total of 137 patients (79 cases and 58 controls) were in

SUBMITTER: Rincon-Lopez EM 

PROVIDER: S-EPMC8329904 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature