Chronic stress promotes glioma cell proliferation via the PI3K/Akt signaling pathway.

ABSTRACT: High malignancy and high mortality of glioma render it urgent to elucidate the underlying mechanisms of glioma carcinogenesis and explore novel targets for therapy. Epidemiologic and clinical studies have revealed that chronic stress promotes the progression of various solid tumors and is correlated with poor prognosis; however, findings reporting the involvement of chronic stress in glioma are rare. In the present study, a chronic restraint animal model and a chronic stress cell model were established to explore the effects of chronic stress on glioma and its molecular mechanisms. The results revealed that chronic stress promoted glioma growth in vivo, and the serum levels of the stress hormones glucocorticoid (GC) and noradrenaline (NE) were significantly increased. In addition, G

SUBMITTER: Zhang ZQ 

PROVIDER: S-EPMC8329913 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature