DNA methylation atlas and machinery in the developing and regenerating annelid Platynereis dumerilii.

ABSTRACT:

Background

Methylation of cytosines in DNA (5mC methylation) is a major epigenetic modification that modulates gene expression and constitutes the basis for mechanisms regulating multiple aspects of embryonic development and cell reprogramming in vertebrates. In mammals, 5mC methylation of promoter regions is linked to transcriptional repression. Transcription regulation by 5mC methylation notably involves the nucleosome remodeling and deacetylase complex (NuRD complex) which bridges DNA methylation and histone modifications. However, less is known about regulatory mechanisms involving 5mC methylation and their function in non-vertebrate animals. In this paper, we study 5mC methylation in the marine annelid worm Platynereis dumerilii, an emerging evolutionary and developmental biol

SUBMITTER: Planques A 

PROVIDER: S-EPMC8330077 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature