Investigating the relationship between multi-scale perfusion and white matter microstructural integrity in patients with relapsing-remitting MS.

ABSTRACT:

Background

Multiple sclerosis is characterized by the formation of central nervous system demyelinating lesions with microvasculature inflammation.

Objective

Evaluate how lesion cerebral perfusion relates to white matter microstructural integrity in patients with RRMS using perfusion MRI and myelin-related T₁-weighted to T₂-weighted (T₁w/T₂w) ratios.

Methods

Forty-eight patients with RRMS were imaged with dynamic susceptibility contrast imaging using SAGE (spin- and gradient-echo) to calculate global and capillary-sized perfusion parameters, including cerebral blood flow (CBF), volume (CBV), and mean transit time (MTT). T₁w/T₂w ratios were used to indirectly assess white matter microstructural integrity

SUBMITTER: Sisco NJ 

PROVIDER: S-EPMC8330486 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature