A hyaluronan synthesis inhibitor delays the progression of diabetic kidney disease in a mouse experimental model.

ABSTRACT:

Background

The role of hyaluronan (HA) in the development and progression of diabetic kidney disease (DKD), as well as the precise mechanisms and consequences of HA involvement in this pathology are still to be clarified.

Methods

In this study, we assayed the effects of the HA synthesis inhibitor 4-methylumbelliferone (4-MU) on the development of DKD. Diabetic type 2 model mice (eNOS^-/- C57BLKS/J^db) were fed artificial diets containing 5% 4-MU or not for 9 weeks. Plasma glucose, glomerular filtration rate (GFR), albumin to creatinine ratio (ACR), and biomarkers of kidney function and systemic inflammation were measured at baseline and after treatment. Diabetic nephropathy was further characterized in treated and control mice by histopathology.

Result

SUBMITTER: Selman G 

PROVIDER: S-EPMC8330520 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature