The PATCH trial: efficacy and safety of 5% lidocaine-medicated plaster for the treatment of patients with trigeminal neuralgia: a study protocol for a multicentric, double-blind, enriched enrolment randomised withdrawal, vehicle-controlled study.

ABSTRACT:

Introduction

Trigeminal neuralgia (TN) is characterised by a sudden, severe, electric shock like paroxysmal pain, which is almost always associated with triggers. Carbamazepine is the first-line medical management of TN. However, side effects are common. Currently, there is no ideal treatment for TN. Since there is a known abnormality of Na⁺ channels in the trigger zone, 5% lidocaine-medicated plaster (LMP), which can block the Na⁺ channels on Aδ and C fibres, is an effective treatment method in many chronic pain conditions. A case report has found the benefit of LMP for the treatment of TN without any side effects. Whether LMP is an option for the treatment of TN is worth exploring.

Methods and analysis

The PATCH trial is a double-blind, enriched enrol

SUBMITTER: Zhao C 

PROVIDER: S-EPMC8330571 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature