Shotgun mass spectrometry-based lipid profiling identifies and distinguishes between chronic inflammatory diseases.

ABSTRACT:

Background

Localized stress and cell death in chronic inflammatory diseases may release tissue-specific lipids into the circulation causing the blood plasma lipidome to reflect the type of inflammation. However, deep lipid profiles of major chronic inflammatory diseases have not been compared.

Methods

Plasma lipidomes of patients suffering from two etiologically distinct chronic inflammatory diseases, atherosclerosis-related vascular disease, including cardiovascular (CVD) and ischemic stroke (IS), and systemic lupus erythematosus (SLE), were screened by a top-down shotgun mass spectrometry-based analysis without liquid chromatographic separation and compared to each other and to age-matched controls. Lipid profiling of 596 lipids was performed on a cohort of 427 individuals

SUBMITTER: Matthiesen R 

PROVIDER: S-EPMC8330692 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature