Epigenomic mediation after adverse childhood experiences: a systematic review and meta-analysis.

ABSTRACT: Epigenetic mechanisms are potential mediators of the physiological response to abuse by altering the genetic predisposition of the cellular response to the environment, leading to changes in the regulation of multiple organ systems. This study was established to review the epigenetic mechanisms associated with childhood abuse as well as the long-term determinants that these epigenetic changes may have on future illness. We retrospectively analysed the effect of exposure to adverse childhood experiences (ACEs, specifically those relating to childhood maltreatment) between the ages of 0 and 16 years on the human epigenome, as well as possible clinical associations. After meeting inclusion and exclusion criteria, 36 articles were included in this systematic review. Eight of these studies did

SUBMITTER: Neves I 

PROVIDER: S-EPMC8330736 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature