Development of an NMR-Based Platform for the Direct Structural Annotation of Complex Natural Products Mixtures.

ABSTRACT: The development of new "omics" platforms is having a significant impact on the landscape of natural products discovery. However, despite the advantages that such platforms bring to the field, there remains no straightforward method for characterizing the chemical landscape of natural products libraries using two-dimensional nuclear magnetic resonance (2D-NMR) experiments. NMR analysis provides a powerful complement to mass spectrometric approaches, given the universal coverage of NMR experiments. However, the high degree of signal overlap, particularly in one-dimensional NMR spectra, has limited applications of this approach. To address this issue, we have developed a new data analysis platform for complex mixture analysis, termed MADByTE (Metabolomics and Dereplication by Two-Dimensional

SUBMITTER: Egan JM 

PROVIDER: S-EPMC8330833 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature