Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells.

ABSTRACT: During the last decade, a consensus has emerged that the stochastic triggering of an excitable system drives pseudopod formation and subsequent migration of amoeboid cells. The presence of chemoattractant stimuli alters the threshold for triggering this activity and can bias the direction of migration. Though noise plays an important role in these behaviors, mathematical models have typically ignored its origin and merely introduced it as an external signal into a series of reaction-diffusion equations. Here we consider a more realistic description based on a reaction-diffusion master equation formalism to implement these networks. In this scheme, noise arises naturally from a stochastic description of the various reaction and diffusion terms. Working on a three-dimensional geometry in whi

SUBMITTER: Biswas D 

PROVIDER: S-EPMC8330952 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature