Screening an Established Natural Product Library Identifies Secondary Metabolites That Potentiate Conventional Antibiotics.

ABSTRACT: Health organizations worldwide have warned that we are on the cusp of a "post-antibiotic era," necessitating new approaches to combat antibiotic resistant infections. One such approach is the development of antibiotic adjuvants, which have little or no inherent antibiotic activity at their active concentrations but instead potentiate the activity of antibiotics against antibiotic-resistant bacteria. Recently, we demonstrated that meridianin D, a natural product originally reported to have activity against Staphylococcus aureus and Mycobacterium tuberculosis, possesses the ability to reverse colistin resistance in colistin resistant bacteria. As most natural product screens typically involve screening for only certain activities (anticancer, antiviral, and antimicrobial are ty

SUBMITTER: Mattingly AE 

PROVIDER: S-EPMC8330956 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature