Ontology highlight
ABSTRACT:
SUBMITTER: Galland L
PROVIDER: S-EPMC8331027 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Galland Loïck L Le Page Anne Laure AL Lecuelle Julie J Bibeau Frederic F Oulkhouir Youssef Y Derangère Valentin V Truntzer Caroline C Ghiringhelli François F
Oncoimmunology 20210802 1
Anti-PD1/PD-L1-directed immune checkpoint inhibitors are game changers in advanced non-small-cell lung cancer, but biomarkers are lacking. The aim of our study was to find clinically relevant biomarkers of the efficacy of ICI in non-squamous NSCLC. We conducted a retrospective study of patients receiving ICI for advanced non squamous NSCLC in two cohorts. For a subset of patients, RNAseq data were generated on tumor biopsy taken before ICI. The primary end point was progression-free survival und ...[more]