Network modules linking expression and methylation in prefrontal cortex of schizophrenia.

ABSTRACT: Tremendous work has demonstrated the critical roles of genetics, epigenetics as well as their interplay in brain transcriptional regulations in the pathology of schizophrenia (SZ). There is great success currently in the dissection of the genetic components underlying risk-conferring transcriptomic networks. However, the study of regulating effect of epigenetics in the etiopathogenesis of SZ still faces many challenges. In this work, we investigated DNA methylation and gene expression from the dorsolateral prefrontal cortex (DLPFC) region of schizophrenia patients and healthy controls using weighted correlation network approach. We identified and replicated two expression and two methylation modules significantly associated with SZ. Among them, one pair of expression and methylation module

SUBMITTER: Lin D 

PROVIDER: S-EPMC8331039 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature