Preoperative imaging of glioblastoma patients using hyperpolarized ¹³C pyruvate: Potential role in clinical decision making.

ABSTRACT:

Background

Glioblastoma remains incurable despite treatment with surgery, radiation therapy, and cytotoxic chemotherapy, prompting the search for a metabolic pathway unique to glioblastoma cells.¹³C MR spectroscopic imaging with hyperpolarized pyruvate can demonstrate alterations in pyruvate metabolism in these tumors.

Methods

Three patients with diagnostic MRI suggestive of a glioblastoma were scanned at 3 T 1-2 days prior to tumor resection using a ¹³C/¹H dual-frequency RF coil and a ¹³C/¹H-integrated MR protocol, which consists of a series of ¹H MR sequences (T₂ FLAIR, arterial spin labeling and contrast-enhanced [CE] T₁) and ¹³C spectroscopic imaging with hyperpolarized [1-

SUBMITTER: Chen J 

PROVIDER: S-EPMC8331053 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature