Non-contrast computed tomography characteristics in a large cohort of cystinuria patients.

ABSTRACT:

Purpose

Cystine stones are widely considered hard and difficult to treat. Hounsfield Units (HU) are used in other stone types to estimate 'hardness' and treatments based on that finding. Our objective was to report mean HU of cystine stones in vivo in a large case series of cystinuria patients and assess for differences in genotype.

Methods

A prospective case series of cystinuria patients referred to a specialist centre was analysed. CT imaging was assessed by two independent radiologists to determine in vivo attenuation of cystine calculi. Mean HU was compared for both cystinuria genes (SLC3A1 and SLC7A9) using an independent t-test.

Results

164 adult cystinuric patients were identified (55% male), median age 43 years (range 18-80). Median follow up was 31 months (IQ

SUBMITTER: Warren H 

PROVIDER: S-EPMC8332560 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature