Detection of prostate cancer with ¹⁸F-DCFPyL PET/CT compared to final histopathology of radical prostatectomy specimens: is PSMA-targeted biopsy feasible? The DeTeCT trial.

ABSTRACT:

Purpose

In primary prostate cancer (PCa) patients, accurate staging and histologic grading are crucial to guide treatment decisions. ¹⁸F-DCFPyL (PSMA)-PET/CT has been successfully introduced for (re)staging PCa, showing high accuracy to localise PCa in lymph nodes and/or osseous structures. The diagnostic performance of ¹⁸F-DCFPyL-PET/CT in localizing primary PCa within the prostate gland was assessed, allowing for PSMA-guided targeted-prostate biopsy.

Methods

Thirty patients with intermediate-/high-risk primary PCa were prospectively enrolled between May 2018 and May 2019 and underwent ¹⁸F-DCFPyL-PET/CT prior to robot-assisted radical prostatectomy (RARP). Two experienced and blinded nuclear medicine physicians assessed tumour localisation w

SUBMITTER: Bodar YJL 

PROVIDER: S-EPMC8332599 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature