Microenvironment of mammary fat pads affected the characteristics of the tumors derived from the induced cancer stem cells.

ABSTRACT: Breast cancer is the first common cause of cancer-related death in women worldwide. Since the malignancy and aggressiveness of breast cancer have been correlated with the presence of breast cancer stem cells, the establishment of a disease model with cancer stem cells is required for the development of a novel therapeutic strategy. Here, we aimed to evaluate the availability of cancer stem cell models developed from mouse induced pluripotent stem cells with the conditioned medium of different subtypes of breast cancer cell lines, the hormonal-responsive T47D cell line and the triple-negative breast cancer BT549 cell line, to generate in vivo tumor models. When transplanted into the mammary fat pads of BALB/c nude mice, these two model cells formed malignant tumors exhibiting pronoun

SUBMITTER: Abu Quora HA 

PROVIDER: S-EPMC8332865 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature