A new BiofilmChip device for testing biofilm formation and antibiotic susceptibility.

ABSTRACT: Currently, three major circumstances threaten the management of bacterial infections: increasing antimicrobial resistance, expansion of chronic biofilm-associated infections, and lack of an appropriate approach to treat them. To date, the development of accelerated drug susceptibility testing of biofilms and of new antibiofouling systems has not been achieved despite the availability of different methodologies. There is a need for easy-to-use methods of testing the antibiotic susceptibility of bacteria that form biofilms and for screening new possible antibiofilm strategies. Herein, we present a microfluidic platform with an integrated interdigitated sensor (BiofilmChip). This new device allows an irreversible and homogeneous attachment of bacterial cells of clinical origin, even directly

SUBMITTER: Blanco-Cabra N 

PROVIDER: S-EPMC8333102 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature