Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals.

ABSTRACT: The aim of the present study is to describe the ongoing spread of the KPC-producing strains, which is evolving to an epidemic in Czech hospitals. During the period of 2018-2019, a total of 108 KPC-producing Enterobacterales were recovered from 20 hospitals. Analysis of long-read sequencing data revealed the presence of several types of bla_KPC-carrying plasmids; 19 out of 25 bla_KPC-carrying plasmids could be assigned to R (n = 12), N (n = 5), C (n = 1) and P6 (n = 1) incompatibility (Inc) groups. Five of the remaining bla_KPC-carrying plasmids were multireplicon, while one plasmid couldn't be typed. Additionally, phylogenetic analysis confirmed the spread of bla_KPC-carrying plasmids among different clones of diverse Enterobacterales species. Our fi

SUBMITTER: Kraftova L 

PROVIDER: S-EPMC8333104 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature