Histological activity despite normal ALT and IgG serum levels in patients with autoimmune hepatitis and cirrhosis.

ABSTRACT:

Background & aims

In autoimmune hepatitis (AIH), normal levels of transaminases and IgG define biochemical remission and are considered the best surrogate markers for histological remission. This study assessed whether this also applies to patients with AIH cirrhosis.

Methods

In this European multicentric study, we included 125 biopsies from 113 patients with AIH and histologically proven cirrhosis; 105 biopsies from 104 patients with AIH without cirrhosis served as controls. Biochemical parameters were available within 4 weeks of biopsy. AIH activity was graded according to the modified Hepatitis Activity Index (mHAI), with mHAI ≥4/18 considered to indicate risk of disease progression.

Results

In total, 47 out of 125 liver biopsies were obtained from patients with AI

SUBMITTER: Laschtowitz A 

PROVIDER: S-EPMC8333110 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature