Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients.

ABSTRACT:

Background

Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. The current study aimed to clarify the role of STAT4 (rs7574865) variant allelic and genotypic variations in the susceptibility to type 1 diabetes among Egyptians by using the real-time PCR.

Results

A total of 100 patients and 100 controls were genotyped for rs7574865, and the biochemical and anthropometric parameters were measured to show that type 1 diabetic patients had significantly higher leve

SUBMITTER: Abdelmajed SS 

PROVIDER: S-EPMC8333174 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature