Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage.

ABSTRACT: PKMζ is an autonomously active PKC isoform crucial for the maintenance of synaptic long-term potentiation (LTP) and long-term memory. Unlike other kinases that are transiently stimulated by second messengers, PKMζ is persistently activated through sustained increases in protein expression of the kinase. Therefore, visualizing increases in PKMζ expression during long-term memory storage might reveal the sites of its persistent action and thus the location of memory-associated LTP maintenance in the brain. Using quantitative immunohistochemistry validated by the lack of staining in PKMζ-null mice, we examined the amount and distribution of PKMζ in subregions of the hippocampal formation of wild-type mice during LTP maintenance and spatial long-term memory storage. During LTP maintenance in h

SUBMITTER: Hsieh C 

PROVIDER: S-EPMC8333175 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature