Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine.

ABSTRACT: Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly relevant for physical and mental well-being; female and male health; in the modulation of senses, pain, stress reactions and drug sensitivity as well as healing processes, amongst others. Shifted ET-1 homeostasis may influence and predict the development and progression of suboptimal health conditions, metabolic impairments with cascading complications, ageing and related pathologies, cardiovascular diseases, neurodegenerative pathologies, aggressive malignancies, modulating, therefore, individual outcomes of both non-communicable and infectious diseases such as COVID-19. This article provides an in-depth analysis of the involvement of ET-1 and related regulatory pathways in physiological and pathophysiologic

SUBMITTER: Torres Crigna A 

PROVIDER: S-EPMC8334338 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature