Increased Proportion of CD226⁺ B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus.

ABSTRACT:

Background

CD226, an activating receptor expressed on the surface of natural killer (NK) cells and T cells, is also seen on B cells and CD226 polymorphism is associated with systemic lupus erythematosus (SLE). Because the specific roles of CD226⁺ B cells in SLE are still unknown, we investigated the association of CD226⁺ B cells with SLE.

Methods

We measured CD226 expression on B cells and its subsets using flow cytometry in 48 SLE patients and 24 healthy controls (HCs). We assessed the relationships between CD226⁺ B cells and SLE Disease Activity Index 2000 (SLEDAI-2K), clinical manifestations, laboratory data, and prognosis after 12 months.

Results

The proportions of CD226⁺ cells in whole B cells and all its subsets were s

SUBMITTER: Nakano M 

PROVIDER: S-EPMC8334729 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature