Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence.

ABSTRACT: It is well known that aging is associated with dysregulated metabolism. This is seen both in terms of systemic metabolism, as well as at the cellular level with clear mitochondrial dysfunction. More recently, the importance of cellular metabolism in immune cells, or immunometabolism, has been highlighted as a major modifier of immune cell function. Indeed, T cell activation, differentiation, and effector function partly depend on alterations in metabolic pathways with different cell types and functionality favoring either glycolysis or oxidative phosphorylation. While immune system dysfunction with aging is well described, what remains less elucidated is how the integral networks that control immune cell metabolism are specifically affected by age. In recent years, this significant gap has

SUBMITTER: Martin DE 

PROVIDER: S-EPMC8334863 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature