Comparative Economic Analysis Between Endogenous and Recombinant Production of Hyaluronic Acid.

ABSTRACT: Hyaluronic acid (HA) is a biopolymer with a wide range of applications, mainly in the cosmetic and pharmaceutical sectors. Typical industrial-scale production utilizes organisms that generate HA during their developmental cycle, such as Streptococcus equi sub. zooepidemicus. However, a significant disadvantage of using Streptococcus equi sub. zooepidemicus is that it is a zoonotic pathogen, which use at industrial scale can create several risks. This creates opportunities for heterologous, or recombinant, production of HA. At an industrial scale, the recovery and purification of HA follow a series of precipitation and filtration steps. Current recombinant approaches are developing promising alternatives, although their industrial implementation has yet to be ade

SUBMITTER: Torres-Acosta MA 

PROVIDER: S-EPMC8334870 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature