The Application of Imaging Flow Cytometry for Characterisation and Quantification of Bacterial Phenotypes.

ABSTRACT: Bacteria modify their morphology in response to various factors including growth stage, nutrient availability, predation, motility and long-term survival strategies. Morphological changes may also be associated with specific physiological phenotypes such as the formation of dormant or persister cells in a "viable but non-culturable" (VBNC) state which frequently display different shapes and size compared to their active counterparts. Such dormancy phenotypes can display various degrees of tolerance to antibiotics and therefore a detailed understanding of these phenotypes is crucial for combatting chronic infections and associated diseases. Cell shape and size are therefore more than simple phenotypic characteristics; they are important physiological properties for understanding bacterial l

SUBMITTER: Power AL 

PROVIDER: S-EPMC8335544 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature