Identification of Somatic Mutation-Driven Immune Cells by Integrating Genomic and Transcriptome Data.

ABSTRACT: Tumor somatic mutations in protein-coding regions may generate neoantigens which may trigger antitumor immune cell response. Increasing evidence supports that immune cell response may profoundly influence tumor progression. However, there are no calculated tools to systematically identify immune cells driven by specific somatic mutations. It is urgent to develop a calculated method to comprehensively detect tumor-infiltrating immune cells driven by the specific somatic mutations in cancer. We developed a novel software package (SMDIC) that enables the automated identification of somatic mutation-driven immune cell. SMDIC provides a novel pipeline to discover mutation-specific immune cells by integrating genomic and transcriptome data. The operation modes include inference of the relative a

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8335569 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature