Exploration of Immune-Related Gene Expression in Osteosarcoma and Association With Outcomes.

ABSTRACT:

Importance

Host immune dysregulation is associated with initiation and development of osteosarcoma. In addition, immunotherapy for osteosarcomas requires some knowledge of the immune state of patients.

Objective

To perform an immunogenomic landscape analysis based on The Cancer Genome Atlas (TCGA) project, which provides osteosarcoma samples with clinical information.

Design, setting, and participants

This genetic association study was conducted from July 20, 2020, to September 20, 2020, as a secondary analysis of public data. Cox regression and risk score analyses were used to construct signatures of immune-related genes (IRGs) in 84 patients with osteosarcoma from TCGA with corresponding clinical information. Patients were divided into high- and low-risk groups with

SUBMITTER: Liu W 

PROVIDER: S-EPMC8335580 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature