Triapine Analogues and Their Copper(II) Complexes: Synthesis, Characterization, Solution Speciation, Redox Activity, Cytotoxicity, and mR2 RNR Inhibition.

ABSTRACT: Three new thiosemicarbazones (TSCs) HL¹-HL³ as triapine analogues bearing a redox-active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL¹-HL³ with CuCl₂·2H₂O in anoxic methanol afforded three copper(II) complexes, namely, Cu(HL¹)Cl₂ (1), [Cu(L²)Cl] (2'), and Cu(HL³)Cl₂ (3), in good yields. Solution speciation studies revealed that the metal-free ligands are stable as HL¹-HL³ at pH 7.4, while being air-sensitive in the basic pH range. In dimet

SUBMITTER: Besleaga I 

PROVIDER: S-EPMC8335727 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature