Beyond the storm - subacute toxicities and late effects in children receiving CAR T cells.

ABSTRACT: As clinical advances with chimeric antigen receptor (CAR) T cells are increasingly described and the potential for extending their therapeutic benefit grows, optimizing the implementation of this therapeutic modality is imperative. The recognition and management of cytokine release syndrome (CRS) marked a milestone in this field; however, beyond the understanding gained in treating CRS, a host of additional toxicities and/or potential late effects of CAR T cell therapy warrant further investigation. A multicentre initiative involving experts in paediatric cell therapy, supportive care and/or study of late effects from cancer and haematopoietic stem cell transplantation was convened to facilitate the comprehensive study of extended CAR T cell-mediated toxicities and establish a framework fo

SUBMITTER: Shalabi H 

PROVIDER: S-EPMC8335746 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature