Interleukin-25: New perspective and state-of-the-art in cancer prognosis and treatment approaches.

ABSTRACT: Cancer is a leading cause of death which imposes a substantial financial burden. Among the several mechanisms involved in cancer progression, imbalance of immune cell-derived factors such as cytokines and chemokines plays a central role. IL-25, as a member of the IL-17 cytokine subfamily, exerts a paradoxical role in cancer, including tumor supportive and tumor suppressive. Hence, we have tried to clarify the role of IL-25 and its receptor in tumor progression and cancer prognosis. It has been confirmed that IL-25 exerts a tumor-suppressive role through inducing infiltration of eosinophils and B cells into the tumor microenvironment and activating the apoptotic pathways. In contrast, the tumor-supportive function has been implemented by activating inflammatory cascades, promoting cell cycl

SUBMITTER: Gowhari Shabgah A 

PROVIDER: S-EPMC8335817 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature