Immune infiltration phenotypes of prostate adenocarcinoma and their clinical implications.

ABSTRACT:

Background

Tumor-infiltrating immune cells participate in the initiation and progression of prostate adenocarcinoma (PRAD). However, it is not fully known how immune infiltration affects the development of PRAD and its clinical presentation.

Methods

Herein, we investigated the immune infiltration phenotypes in PRAD based on transcriptome profiles, methylation profiles, somatic mutation, and copy number variations. We also developed an immune prognostic model (IPM) to identify unfavorable prognosis. To verify this model, immunohistochemistry staining was performed on a cohort of PRAD samples. Moreover, we constructed a nomogram to assess the survival of PRAD incorporating immune infiltration and other clinical features.

Results

We categorized PRAD patients into high an

SUBMITTER: Ma Z 

PROVIDER: S-EPMC8335836 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature