SPM Receptor Expression and Localization in Irradiated Salivary Glands.

ABSTRACT: Radiation therapy-mediated salivary gland destruction is characterized by increased inflammatory cell infiltration and fibrosis, both of which ultimately lead to salivary gland hypofunction. However, current treatments (e.g., artificial saliva and sialagogues) only promote temporary relief of symptoms. As such, developing alternative measures against radiation damage is critical for restoring salivary gland structure and function. One promising option for managing radiation therapy-mediated damage in salivary glands is by activation of specialized proresolving lipid mediator receptors due to their demonstrated role in resolution of inflammation and fibrosis in many tissues. Nonetheless, little is known about the presence and function of these receptors in healthy and/or irradiated salivary

SUBMITTER: Dos Santos HT 

PROVIDER: S-EPMC8335844 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature