Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice.

ABSTRACT: The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain barrier, posing a particular challenge for treatment. We report biological features of invasive growth accompanying tumor progression and invasion based on associated metabolic and transcriptomic changes observed in patient derived orthotopic xenografts (PDOX) in the mouse and the corresponding patients' tumors. The evolution of metabolic changes, followed in vivo longitudinally by ¹H Magnetic Resonance Spectroscopy (¹H MRS) at ultra-high field, reflected growth and the invasive properties of the human glioblastoma

SUBMITTER: Cudalbu C 

PROVIDER: S-EPMC8336020 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature