Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria.

ABSTRACT:

Background

Plasmodium falciparum is an obligate intracellular parasite of humans that causes malaria. Falciparum malaria is a major public health threat to human life responsible for high mortality. Currently, the risk of multi-drug resistance of P. falciparum is rapidly increasing. There is a need to address new anti-malarial therapeutics strategies to combat the drug-resistance threat.

Methods

The P. falciparum essential proteins were retrieved from the recently published studies. These proteins were initially scanned against human host and its gut microbiome proteome sets by comparative proteomics analyses. The human host non-homologs essential proteins of P. falciparum were additionally analysed for druggability potential via in silico methods to possibly identify novel

SUBMITTER: Ali F 

PROVIDER: S-EPMC8336052 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature