Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery.

ABSTRACT:

Background

Retrospective studies suggested that storage age of RBCs is associated with inflammation and thromboembolism. The Red Cell Storage Duration Study (RECESS) trial randomized subjects undergoing complex cardiac surgery to receive RBCs stored for shorter versus longer periods, and no difference was seen in the primary outcome of change in multiple organ dysfunction score.

Study design and methods

In the current study, 90 subjects from the RECESS trial were studied intensively using a range of hemostasis, immunologic, and nitric oxide parameters. Samples were collected before transfusion and on Days 2, 6, 28, and 180 after transfusion.

Results

Of 71 parameters tested, only 4 showed a significant difference after transfusion between study arms: CD8+ T-cell interf

SUBMITTER: Spinella PC 

PROVIDER: S-EPMC8336068 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature