A Wirelessly Controlled Smart Bandage with 3D-Printed Miniaturized Needle Arrays.

ABSTRACT: Chronic wounds are one of the most devastating complications of diabetes and are the leading cause of nontraumatic limb amputation. Despite the progress in identifying factors and promising in vitro results for the treatment of chronic wounds, their clinical translation is limited. Given the range of disruptive processes necessary for wound healing, different pharmacological agents are needed at different stages of tissue regeneration. This requires the development of wearable devices that can deliver agents to critical layers of the wound bed in a minimally invasive fashion. Here, for the first time, a programmable platform is engineered that is capable of actively delivering a variety of drugs with independent temporal profiles through miniaturized needles into deeper layers of the wound

SUBMITTER: Derakhshandeh H 

PROVIDER: S-EPMC8336080 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature