Association between CD4⁺ T cell counts and gut microbiota and serum cytokines levels in HIV-infected immunological non-responders.

ABSTRACT:

Background

CD4⁺ T cell counts in certain human immunodeficiency virus (HIV)-infected patients called immunological non-responders (INRs) could not return to a normal level even with sustained antiretroviral therapy (ART) because of persistent immune activation, which is associated with pro-inflammatory cytokines production and an altered intestinal microbiome profile. Changes in gut bacterial composition have been linked to low CD4⁺ T cell counts in HIV-infected individuals. However, the association between CD4⁺ T cell counts and gut microbiota community composition and cytokines levels in INRs (CD4⁺ T cell counts < 500 cells/μL) from Yunnan Province, China, has not been previously investigated.

Methods

To address this issue, we ca

SUBMITTER: Lu D 

PROVIDER: S-EPMC8336095 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature