Titanium dioxide nanoparticles enhance thrombosis through triggering the phosphatidylserine exposure and procoagulant activation of red blood cells.

ABSTRACT:

Background

Expanding biomedical application of anatase titanium dioxide (TiO₂) nanoparticles (NPs) is raising the public concern on its potential health hazards. Here, we demonstrated that TiO₂ NPs can increase phosphatidylserine (PS) exposure and procoagulant activity of red blood cells (RBCs), which may contribute to thrombosis.

Results

We conducted in vitro studies using RBCs freshly isolated from healthy male volunteers. TiO₂ NPs exposure (≦ 25 μg/mL) induced PS exposure and microvesicles (MV) generation accompanied by morphological changes of RBCs. While ROS generation was not observed following the exposure to TiO₂ NPs, intracellular calcium increased and caspase-3 was activated, which up-regulated scramblase activity, leadin

SUBMITTER: Bian Y 

PROVIDER: S-EPMC8336274 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature